Chemical Name:N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-m
ethylphenyl)amino]carbonyl]-L-lysyl-L-a-aspartyl-Na-met
hyl-L-phenylalaninamide
Biological Activity:
Potent
CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity
over the CCK2 receptor. Suppresses food intake following central or
peripheral administration.
DeNinnoet al (1990) Development of
CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists.
J.Med.Chem. 33 2951. Linet al (1990)
Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues,
A-71623 and A-70874, that exhibit high potency and selectivity for
cholecystokinin-A receptors. Mol.Pharmacol. 39 346. Asinet
al (1992) A-71623, a selective CCK-A receptor agonist, suppresses food
intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 42
699.
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