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Prostanoid Receptors
More Information »Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2α, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.
Prostanoid Receptor Products
Agonists |
|
Cat.No. |
Product Name / Activity |
| 1442 | BMY 45778 |
| Non-prostanoid prostacyclin IP receptor partial agonist | |
| 2295 | (±)-Cloprostenol sodium salt |
| Water-soluble PGF2α analog and potent FP receptor agonist | |
| 4027 | 16,16-Dimethyl Prostaglandin E2 |
| Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development | |
| 2989 | Epoprostenol |
| Endogenous IP receptor agonist | |
| 4542 | (+)-Fluprostenol |
| High affinity FP prostaglandin receptor agonist | |
| 2038 | Iloprost |
| Prostacyclin (PGI2) analog | |
| 4757 |
Latanoprost
|
| FP prostaglandin receptor agonist; also exhibits agonist activity at EP1 and EP3 receptors | |
| 2297 | Misoprostol |
| Cytoprotective PGE1 analog | |
| 2296 | Prostaglandin E2 |
| Major endogenous prostanoid | |
| 4214 | Prostaglandin F2α |
| Naturally-occurring prostanoid; potent vasoconstrictor | |
| 3049 | Sulprostone |
| EP3 and EP1 receptor agonist | |
| 4069 | TCS 2510 |
| Selective EP4 agonist | |
| 4218 | Travaprost |
| Potent and selective FP prostaglandin receptor agonist | |
| 1932 | U 46619 |
| Potent, stable thromboxane A2 (TP) receptor agonist | |
Antagonists |
|
Cat.No. |
Product Name / Activity |
| 3025 | AA 2414 |
| Thromboxane A2 (TP) receptor antagonist | |
| 0671 | AH 6809 |
| EP1 and EP2 receptor antagonist | |
| 2732 | BAY-u 3405 |
| Dual TP/DP2 (CRTH2) receptor antagonist | |
| 0836 | ICI 185,282 |
| Potent thromboxane receptor antagonist | |
| 0837 | ICI 192,605 |
| Potent thromboxane A2/TP receptor antagonist | |
| 2514 | L-161,982 |
| Selective EP4 receptor antagonist | |
| 1698 | L-655,240 |
| Potent, selective thromboxane A2/prostaglandin endoperoxide antagonist | |
| 1949 | L-670,596 |
| Potent, selective thromboxane A2/prostaglandin endoperoxide antagonist | |
| 3342 | L-798,106 |
| Potent and highly selective EP3 antagonist | |
| 4818 |
PF 04418948
|
| Potent and selective EP2 receptor antagonist | |
| 1206 | SC 19220 |
| Selective EP1 receptor antagonist | |
| 3758 | SC 51089 |
| Selective EP1 receptor antagonist | |
| 2791 | SC 51322 |
| Potent EP1 receptor antagonist | |
Other |
|
Cat.No. |
Product Name / Activity |
| 1620 | Alprostadil |
| Prostaglandin. Vasodilator and antiplatelet agent in vivo | |
| 2756 | Arachidonic acid (in Tocrisolve™100) |
| Endogenous free fatty acid (in water-soluble emulsion) | |
| 1510 | Ozagrel hydrochloride |
| Selective thromboxane A2 synthetase inhibitor | |
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