R&D Systems Inc. Tocris Bioscience Boston Biochem

Hedgehog Signaling Pathway

Pathway Key Download PDF

The Hedgehog (Hh) signaling pathway is important in the regulation of several developmental processes. It controls morphogenesis of organs and tissues in the embryo and the proliferation of stem cells in adult tissues. Disruption of Hh pathways in the embryo can result in severe developmental disorders, or cancer in adults. The mammalian Hh pathway is depicted here.

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Signaling Pathway Key
Stimulates
Stimulates
Inhibits
Inhibits
Multistep Activation
Multistep Activation
Upregulation
Upregulates
Translocates
Translocates
Kinase
Kinase
Transcription Factor
Transcription Factor
Other Protein
Other Protein
7-TM Receptor
7-TM Receptor
12-TM Receptor
12-TM Receptor