R&D Systems Inc. Tocris Bioscience Boston Biochem

NF-κB Signaling Pathway

Pathway Key Download PDF

Nuclear factor kappa B signaling plays an important role in inflammation and the immune and stress responses. Adaptor proteins recruit the IKK complex which phosphorylates and degrades IκB, allowing NF-κB to translocate to the nucleus. Dysregulation of NF-κB signaling can lead to inflammatory and autoimmune disease and cancer.

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Signaling Pathway Key
Stimulates
Stimulates
Inhibits
Inhibits
Multistep Activation
Multistep Activation
Translocates
Translocates
Kinase
Kinase
Transcription Factor
Transcription Factor
Enzyme-linked Receptor
Enzyme-linked Receptor
Other Protein
Other Protein
Nuclear Receptor
Nuclear Receptor