Receptor p53 PKCα PDK1 Akt p90 RSK p70 S6K Wnt AMPK GSK-3 PPARγ PP2A Autophagy Rapamycin Angiogenesis mTOR mTOR PI3K
mTOR (mammalian target of Rapamycin) integrates signals both intrcellularly and extracellularly to regulate growth, proliferation, metabolism and survival. It can form two complexes within the cell, known as mTORC1 and mTORC2 which are dependent on their regulatory proteins Raptor and Rictor respectively. mTOR is important for both the Akt and insulin signal transduction pathways and is deregulated in cancer and Type 2 diabetes.
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