R&D Systems Inc. Tocris Bioscience Boston Biochem

mTOR Signaling Pathway

Pathway Key Download PDF

mTOR (mammalian target of Rapamycin) integrates signals both intrcellularly and extracellularly to regulate growth, proliferation, metabolism and survival. It can form two complexes within the cell, known as mTORC1 and mTORC2 which are dependent on their regulatory proteins Raptor and Rictor respectively. mTOR is important for both the Akt and insulin signal transduction pathways and is deregulated in cancer and Type 2 diabetes.

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Signaling Pathway Key
Stimulates
Stimulates
Inhibits
Inhibits
Multistep Inhibition
Multistep Inhibition
Multistep Activation
Multistep Activation
Multistep Upregulation
Multistep Upregulation
Kinase
Kinase
Transcription Factor
Transcription Factor
Enzyme-linked Receptor
Enzyme-linked Receptor
Other Enzyme
Other Enzyme
Other Protein
Other Protein
7-TM Receptor
7-TM Receptor
Phosphatase
Phosphatase