MAPK Signaling Pathway
MEK ERK1/2 ERK1/2 JNK JNK c-Jun c-Fos STAT
1/3 Raf RTK Raf Ras Ras Hsps p53 p53 PLC PKC PKA p90 RSK EGF p90 RSK Apoptosis Integrin
Receptor FAK Src PI3K Rac Rac cAMP p38
MAPK p38
MAPK p38
MAPK ASK c-Myc
1/3 Raf RTK Raf Ras Ras Hsps p53 p53 PLC PKC PKA p90 RSK EGF p90 RSK Apoptosis Integrin
Receptor FAK Src PI3K Rac Rac cAMP p38
MAPK p38
MAPK p38
MAPK ASK c-Myc
The mitogen-activated protein kinase (MAPK) family is a group of serine/threonine kinases that mediate intracellular signaling. The activation of MAPK involves a cascade consisting of MAPK kinase (also known as MAPKKK or MEKK) that activates MAPK/ERK (also known as MAPKK or MEK). This stimulates a phosphorylation-dependent increase in the activity of MAPK.
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Signaling Pathway Key
Stimulates
Inhibits
Multistep Activation
Upregulates
Translocates
Kinase
Transcription Factor
Enzyme-linked Receptor
Other Enzyme
Other Protein
