Life Science Posters
A range of posters authored by leading experts
Authored by leading experts in the field, and summarizing key areas of research, the following range of life science posters provide a colorful and informative source of information. We invite you to request your copy today.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.Request copy | Download PDF
A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.Request copy
Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.Request copy
Patrice Codogno, University Paris-Descartes
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.Request copy | Download PDF
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
Since going to print, the authors of this poster have notified us of an improvement they wish to make: under the Gq/11 heading, M2 should be amended to M3.Request copy
Checkpoint kinases are a group of enzymes which regulate the progression of a cell through the cell cycle. This poster summarizes the response of the checkpoint kinase signaling network to DNA damage, including activation of DNA repair, cell-cycle arrest, senescence and apoptosis. It also highlights the different types of DNA damage that can occur and some of the treatment methods that are utilized in cancer.Request copy
Piotr Popik, Jagiellonian University
Ramon Trullas, Consejo Superior de Investigaciones Científicas (CSIC)
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.Request copy | Download PDF
The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.Request copy
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.Request copy | Download PDF
p53 is a key transcriptional regulator that is found to be frequently mutated and inactivated in tumors. This poster summarizes the main strategies that may be utilized to reactivate p53 including several small molecules and peptides which act to stabilize p53 and rescue wild-type activity.Request copy
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.Request copy | Download PDF
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.Request copy | Download PDF
Guy Salvesen, Sanford-Burnham Medical Research Institute
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.Request copy | Download PDF
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster highlights the targets and pathways representing the most promising strategies to pursue for novel drug development.Request copy
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Highlights 130 new products added in the first half of 2015. View PDF today.
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