Life Science Posters

7-TM

Seven Transmembrane Receptor Signaling

Seven-transmembrane (7-TM)-receptors are now recognized as complex processors of information that can bind to molecules and cytosolic interactants on the cell membrane. The 7-TM poster highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy.

Alzheimer's

The Neurobiology of Alzheimer's Disease

Alzheimer's disease is the most common form of dementia, affecting approximately 26.6 million people worldwide. This poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease.

Angiogenesis

Tumor- and Stromal Cell-Derived Pathways as Targets for Anti-Angiogenic Therapy

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.

Asthma

New Therapies, Challenges, and Breakthroughs in Asthma

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Autophagy

Autophagy: Mechanisms and Function

Autophagy is a cellular process used by cells for degradation and recycling. This poster summarizes the molecular machinery, physiology and pathology of autophagy.

Cardiovascular

Regulation of Vascular Reactivity by G-protein-coupled Receptors

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Since going to print, the authors of this poster have notified us of an improvement they wish to make: under the G_q/11 heading, M₂ should be amended to M₃.

Cell Cycle Kinases

Checkpoint Kinases and the DNA Damage Response

Checkpoint kinases are a group of enzymes which regulate the progression of a cell through the cell cycle. This poster summarizes the response of the checkpoint kinase signaling network to DNA damage, including activation of DNA repair, cell-cycle arrest, senescence and apoptosis. It also highlights the different types of DNA damage that can occur and some of the treatment methods that are utilized in cancer.

Depression

Antidepressants - Current and Future Targets

Major depressive disorder (MDD) effects approximately 15% of the population in developed countries. This poster provides an overview of the current and future targets for the treatment of MDD.

Gut Hormones

Gut Hormones and the Regulation of Appetite

The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.

Neuroprotection

Calcium Imbalance and Neuroprotective Targets in Cerebral Ischemia and Brain Injury

After cerebral ischemia and brain injury, a wide spectrum of pathophysiological mechanisms are activated. This poster summarizes the key receptors, transporters and intracellular signals that might reveal a neuroprotective target for stroke, trauma and neurodegeneration.

p53

Strategies to Reactivate the p53 Tumor Suppressor Response

p53 is a key transcriptional regulator that is found to be frequently mutated and inactivated in tumors. This poster summarizes the main strategies that may be utilized to reactivate p53 including several small molecules and peptides which act to stabilize p53 and rescue wild-type activity.

Parkinson's

Neurobiology and Therapeutics of Parkinson's Disease

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. The Parkinson's disease poster highlights the neurobiology of the disease and highlights current and new therapeutic interventions.

Programmed Cell Death

Apoptosis, Necroptosis and Cell Survival

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Schizophrenia

Schizophrenia: Emerging Targets and Therapeutic Strategies

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster highlights the targets and pathways representing the most promising strategies to pursue for novel drug development.