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SKF 86002 dihydrochloride

Cat. No. 2008

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Chemical Name: 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2,1-b]thiazole dihydrochloride

Biological Activity

Inhibitor of p38 MAP kinase (IC₅₀ = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC₅₀ = 1 μM). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC₅₀ values are 10 and 100 μM respectively). Anti-inflammatory following oral administration in vivo.

Technical Data

M.Wt:

370.27

Formula:

C₁₆H₁₂FN₃S.2HCl

Solubility:

Soluble to 50 mM in water

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

72873-74-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Griswold et al (1987) SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem.Pharmacol. 36 3463. PMID: 2823821.

Lee et al (1994) A protein kinase involved in the regulaton of inflammatory cytokine biosynthesis. Nature 372 739. PMID: 7997261.

Nick et al (1997) Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J.Clin.Invest. 99 975. PMID: 9062356.

If you know of a relevant citation for this product please let us know.

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Keywords: SKF 86002 dihydrochloride, supplier, p38, MAP, kinases, inhibitors, anti-inflammatory, agent, human, monocyte, IL-1, TNF-α, TNF-alpha, production, Mitogen-Activated, Protein, Kinase, MAPK, Signaling, Signalling, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, SKF86002, dihydrochloride

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