Cat. No. 2007
Chemical Name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester
Biological ActivityHigh affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Johnson (1995) The anti-inflammatory profile of fluticasone propionate. Allergy 50 11. PMID: 7604948.
Smith and Kreutner (1998) In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneim.-Forsch. 48 956.
Zhang et al (2000) Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone. Eur.J.Pharmacol. 406 325. PMID: 11040338.
Pan et al (2012) Potentiation of the Kv1 family K+ channel by cortisone analogues. ACS Chem.Biol. 7 1641. PMID: 22803826.
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Keywords: Fluticasone propionate, supplier, Selective, high, affinity, glucocorticoid, agonists, Receptors, GlaxoSmithKline, GSK
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