Cat. No. 1984
Alternative Names: NEP1-40, Nogo Extracellular Peptide, 1-40
Biological ActivityPeptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal growth, but does not reduce myelin-associated glycoprotein (MAG) inhibition of neurite outgrowth in vitro. Promotes regeneration of hemisected spinal axons and locomotor recovery following spinal injury in vivo.
(Modifications: Arg-1 = N-terminal Ac, Ser-40 = C-terminal amide)
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Certificate of Analysis / Safety Data Sheet
GrandPre et al (2002) Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 417 547. PMID: 12037567.
Liu et al (2002) Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297 1190. PMID: 12089450.
Li and Strittmatter (2003) Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J.Neurosci. 23 4219. PMID: 12764110.
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Keywords: Nogo-66 (1-40), supplier, Competitive, antagonists, Nogo-66, receptor, NGR, neuron, regeneration, NEP140