740 Y-P

Cat. No. 1983

740 Y-P Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-pTyr-Met-Asp-Met-Ser

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Alternative Name: PDGFR740Y-P

Biological Activity

Cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.

Technical Data


(Modifications: Tyr-21 = pTyr)

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Derossi et al (1998) Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem.Biophys.Res.Comm. 251 148.

Williams and Doherty (1999) Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol.Cell.Neurosci. 13 272. PMID: 10328886.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: 740 Y-P, supplier, Cell-permeable, PI, 3-kinase, activators, PI3K, 740YP, phosphopeptide, activator, p85, PI 3-kinase Activators

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