Cat. No. 1983
Alternative Name: PDGFR740Y-P
Biological ActivityCell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.
(Modifications: Tyr-25 = pTyr)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Derossi et al (1998) Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem.Biophys.Res.Comm. 251 148.
Williams and Doherty (1999) Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol.Cell.Neurosci. 13 272. PMID: 10328886.
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Keywords: 740 Y-P, supplier, Cell-permeable, PI, 3-kinase, activators, PI3K, 740YP, phosphopeptide, activator, p85
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