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L-803,087 trifluoroacetate

Cat. No. 1979

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Chemical Name: N²-[4-(5,7-Difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-L-arginine methyl ester trifluoroacetate

Biological Activity

Potent and selective somatostatin sst₄ receptor agonist. K_i values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst₄, sst₁, sst₂, sst₃ and sst₅ receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo.

Technical Data

M.Wt:

599.56

Formula:

C₂₅H₂₉F₂N₅O₃.CF₃CO₂H

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>97 %

Storage:

Store at -20°C

CAS No:

217480-26-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Rohrer et al (1998) Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 282 737. PMID: 9784130.

Rohrer and Schaeffer (2000) Identification and characterization of subtype selective somatostatin receptor agonists. J.Physiol.Paris 94 211. PMID: 11087999.

Moneta et al (2002) Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur.J.Neurosci. 16 843. PMID: 12372020.

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Keywords: L-803,087 trifluoroacetate, supplier, Potent, selective, sst4, agonists, Receptors, Somatostatin, L803087

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