Cat. No. 1969
Chemical Name: α-[Amino[(4-aminophenyl)thio]methyle
Biological ActivitySelective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Atkins et al (1998) The MAPK cascade is required for mammalian associative learning. Nature Neurosci. 1 602.
Davis et al (2000) The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J.Neurosci. 20 4563. PMID: 10844026.
Scherle et al (2000) Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J.Biol.Chem. 275 37086. PMID: 10969080.
Wang et al (2003) Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J.Pharmacol.Exp.Ther. 304 172. PMID: 12490588.
If you know of a relevant citation for this product please let us know.
Keywords: SL 327, supplier, Selective, inhibitors, MEK1, MEK2, brain, penetrant, Mitogen-Activated, Protein, Kinase, MEK, Kinases, SL327
Find multiple products by catalog number
New Products in this Area
TGF-β-activated kinase (TAK1) inhibitorMI 14
Potent and selective PI 4-kinase IIIβ inhibitorCTA 056
ITK inhibitorAZD 1480
Potent and selective JAK2 inhibitor; antiangiogenicTC-S 7001
Potent and highly selective ROCK inhibitor; orally activeAS 2444697
Potent and selective IRAK4 inhibitorBS 181 dihydrochloride
Selective cdk7 inhibitorA66
Potent and selective PI 3-kinase p110α inhibitorAZ 191
Potent DYRK1B inhibitorETP 45658
Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTORPFK 15
PFKFB3 inhibitorPD 0332991 isethionate
Potent, selective Cdk4/6 inhibitor; brain penetrantXL 413 hydrochloride
Potent and selective Cdc7 inhibitorC16
PKR inhibitorRp-8-pCPT-cGMPS sodium
PKG inhibitorTC-S 7004
Potent and selective DYRK1A/B inhibitorTAK 960 hydrochloride
Potent and selective PLK1 inhibitor
One Day Symposium
January 12, 2016