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AS 19Cat. No. 1968 |
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Chemical Name: (2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin |
Biological Activity
Potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo.Certificate of Analysis / Safety Data Sheet
References
Perez-Garcia and Meneses (2005) Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav.Brain Res. 163 136. PMID: 15936093.
Perez-Garcia et al (2006) An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation. Behav.Brain Res. 169 83. PMID: 16480781.
Horiguchi et al (2011) The role of 5-hydroxytrpytamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. J.Pharmacol.Exp.Ther. 338 605. PMID: 21558435.
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Keywords: AS 19, supplier, potent, 5-HT7, agonists, serotonin, receptors, 5-Hydroxytryptamine, agonist, AS19
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