R&D Systems Inc. Tocris Bioscience Boston Biochem

Decitabine

Cat. No. 2624

Decitabine C8H12N4O4 [2353-33-5]

Price and Availability

For Decitabine pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: 2'-Deoxy-5-azacytidine, 5-Aza-2'-deoxycytidine, NSC 127716

Chemical Name: 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one

Biological Activity

Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.

Technical Data

M.Wt:
228.21
Formula:
C8H12N4O4
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
2353-33-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Jackson-Grusby et al (1997) Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase. Proc.Natl.Acad.Sci.USA 94 4681.

Bender et al (1998) Inhibition of DNA methylation by 5-aza-2'-deoxycytidine supresses the growth of human tumour cell lines. Cancer Res. 58 95. PMID: 9426064.

Momparler (2005) Pharmacology of 5-aza-2'-deoxycytidine (decitabine). Semin.Hematol. 42 (Suppl 2) S9. PMID: 16015507.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Decitabine, supplier, DNA, methyltransferase, inhibitors, Transferases, stem, cells, NSC127716, epigenetics, 5-Aza-2'-deoxycytidine, 2'-Deoxy-5-azacytidine

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Epigenetics Research Bulletin

Epigenetics Research Bulletin

Includes up to date information and products for epigenetics research. View PDF today.

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

New Products in this Area

A 366

Potent and selective G9a/GLP histone lysine methyltransferase inhibitor

STF 118804

NAMPT inhibitor

SGI 1027

DNA methyltransferase inhibitor

Wnt-C59

Highly potent Porcn inhibitor

C 21

Selective PRMT1 arginine methyltransferase inhibitor

C 21

Selective PRMT1 arginine methyltransferase inhibitor

TC-E 5003

Selective PRMT1 arginine methyltransferase inhibitor

TC-E 5003

Selective PRMT1 arginine methyltransferase inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Pharmacology 2014

Pharmacology 2014

December 16 - 18, 2014

London, UK

Booth Number: 12