R&D Systems Inc. Tocris Bioscience Boston Biochem

Decitabine

Cat. No. 2624

Decitabine C8H12N4O4 [2353-33-5]

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Alternative Names: 2'-Deoxy-5-azacytidine, 5-Aza-2'-deoxycytidine, NSC 127716

Chemical Name: 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one

Biological Activity

Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.

Technical Data

M.Wt:
228.21
Formula:
C8H12N4O4
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
2353-33-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Jackson-Grusby et al (1997) Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase. Proc.Natl.Acad.Sci.USA 94 4681.

Bender et al (1998) Inhibition of DNA methylation by 5-aza-2'-deoxycytidine supresses the growth of human tumour cell lines. Cancer Res. 58 95. PMID: 9426064.

Momparler (2005) Pharmacology of 5-aza-2'-deoxycytidine (decitabine). Semin.Hematol. 42 (Suppl 2) S9. PMID: 16015507.

If you know of a relevant citation for this product please let us know.

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Keywords: Decitabine, supplier, DNA, methyltransferase, inhibitors, Transferases, stem, cells, NSC127716, epigenetics, 5-Aza-2'-deoxycytidine, 2'-Deoxy-5-azacytidine

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