R&D Systems Inc. Tocris Bioscience Boston Biochem

Decitabine

Cat. No. 2624

Decitabine C8H12N4O4 [2353-33-5]

Price and Availability

For Decitabine pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: 2'-Deoxy-5-azacytidine, 5-Aza-2'-deoxycytidine, NSC 127716

Chemical Name: 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one

Biological Activity

Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.

Technical Data

M.Wt:
228.21
Formula:
C8H12N4O4
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
2353-33-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Jackson-Grusby et al (1997) Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase. Proc.Natl.Acad.Sci.USA 94 4681.

Bender et al (1998) Inhibition of DNA methylation by 5-aza-2'-deoxycytidine supresses the growth of human tumour cell lines. Cancer Res. 58 95. PMID: 9426064.

Momparler (2005) Pharmacology of 5-aza-2'-deoxycytidine (decitabine). Semin.Hematol. 42 (Suppl 2) S9. PMID: 16015507.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Decitabine, supplier, DNA, methyltransferase, inhibitors, Transferases, stem, cells, NSC127716, epigenetics, 5-Aza-2'-deoxycytidine, 2'-Deoxy-5-azacytidine

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Epigenetics Research Bulletin

Epigenetics Research Bulletin

A research bulletin containing up-to-date information and products for epigenetics research - view PDF today.

divider line

Epigenetics Review

Epigenetics Review

Written by Susanne Müller-Knapp and Peter J. Brown. Request a copy or view PDF today.

divider line

New Product Guide

NPG

Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

MM 102

WDR5/MLL interaction inhibitor

CRID3 sodium salt

Glutathione S-transferase omega 1 (GSTO1) inhibitor

UNC 2327

Allosteric inhibitor of PRMT3

Furamidine dihydrochloride

Selective PRMT1 inhibitor

XY1

Negative control of SGC 707 (Cat. No. 5367)

SGC 707

Potent and selective allosteric inhibitor of PRMT3

IWP 12

Potent PORCN inhibitor; active in vivo

AZD 3988

Potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitor

WDR5 0103

WDR5 antagonist

UNC 2400

Negative control of UNC 1999 (Cat. No. 4904)

UNC 1999

Potent and selective EZH2/EZH1 inhibitor

Garcinol

PCAF/p300 inhibitor; anticancer

(S)-PFI 2 hydrochloride

Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.