Gossypol

Cat. No. 1964

Gossypol C30H30O8 [303-45-7]

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Chemical Name: 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde

Biological Activity

Lipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL. R-enantiomer available (Cat. No. 3367).

Technical Data

M.Wt:
518.56
Formula:
C30H30O8
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
303-45-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Vander Jagt et al (2000) Gosspyol: prototype of inhibitors targeted to dinucleotide folds. Curr.Med.Chem. 7 479. PMID: 10702620.

Coutinh (2002) Gossypol: a contraceptive for men. Contraception 65 259. PMID: 12020773.

Zhang et al (2003) Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem.Pharmacol. 66 93. PMID: 12818369.

If you know of a relevant citation for this product please let us know.

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Keywords: Gossypol, supplier, Pro-apoptotic, downregulates, Bcl-2, Bcl-XL, Bax, Mcl-1, Family

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