Home » Cellular Processes » Apoptosis » Bcl-2 Family » Gossypol

Gossypol

Cat. No. 1964

Price and Availability

For Gossypol pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde

Biological Activity

Lipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL. R-enantiomer available (Cat. No. 3367).

Technical Data

M.Wt:

518.56

Formula:

C₃₀H₃₀O₈

Solubility:

Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

303-45-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

R-enantiomer Available

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Vander Jagt et al (2000) Gosspyol: prototype of inhibitors targeted to dinucleotide folds. Curr.Med.Chem. 7 479. PMID: 10702620.

Coutinh (2002) Gossypol: a contraceptive for men. Contraception 65 259. PMID: 12020773.

Zhang et al (2003) Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem.Pharmacol. 66 93. PMID: 12818369.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Apoptosis

Bcl-2 Family

Keywords: Gossypol, supplier, Pro-apoptotic, downregulates, Bcl-2, Bcl-XL, Bax, Mcl-1, Family

Quick Order

Find multiple products by catalog number

Cancer Research Guide

Request your free copy

Highlights over 350 products for cancer research. Request a copy or view PDF today.

Neurobiology of Parkinson's Disease

Written by A. Schapira

'Neurobiology and Therapeutics of Parkinson's Disease' highlights the neurobiology of Parkinson's disease and summarizes current and novel therapeutic interventions.

Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

A summary of the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation. Request a copy or view PDF today.