R&D Systems Inc. Tocris Bioscience Boston Biochem

Gossypol

Cat. No. 1964

Gossypol C30H30O8 [303-45-7]

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Chemical Name: 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde

Biological Activity

Lipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL. R-enantiomer available (Cat. No. 3367).

Technical Data

M.Wt:
518.56
Formula:
C30H30O8
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
303-45-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Vander Jagt et al (2000) Gosspyol: prototype of inhibitors targeted to dinucleotide folds. Curr.Med.Chem. 7 479. PMID: 10702620.

Coutinh (2002) Gossypol: a contraceptive for men. Contraception 65 259. PMID: 12020773.

Zhang et al (2003) Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem.Pharmacol. 66 93. PMID: 12818369.

If you know of a relevant citation for this product please let us know.

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Keywords: Gossypol, supplier, Pro-apoptotic, downregulates, Bcl-2, Bcl-XL, Bax, Mcl-1, Family

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