Cat. No. 2983
Alternative Names: Galardin, Ilomastat
Chemical Name: (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indo
Biological ActivityBroad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Grobelny et al (1992) Inhibition of skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31 7152. PMID: 1322694.
Chao et al (2007) Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells. Eur.J.Pharmacol. 573 49. PMID: 17678888.
Shichi et al (2011) Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. J.Pharmacol.Exp.Ther. 338 701. PMID: 21602423.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: GM 6001, supplier, GM6001, matrix, metalloproteases, metalloproteinases, MMPs, broad-spectrum, inhibitors, inhibits, Ilomastat, Galardin
Find multiple products by catalog number
New Products in this Area
Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitorSD 2590 hydrochloride
Potent MMP inhibitorAliskiren hemifumarate
Potent renin inhibitor; antihypertensiveSpautin 1
USP10 and USP13 inhibitor; inhibits autophagy
July 4 - 9, 2015