R&D Systems Inc. Tocris Bioscience Boston Biochem

GM 6001

Cat. No. 2983

GM 6001 C20H28N4O4 [142880-36-2]

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Alternative Names: Galardin, Ilomastat

Chemical Name: (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide

Biological Activity

Broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).

Technical Data

M.Wt:
388.46
Formula:
C20H28N4O4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
142880-36-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Grobelny et al (1992) Inhibition of skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31 7152. PMID: 1322694.

Chao et al (2007) Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells. Eur.J.Pharmacol. 573 49. PMID: 17678888.

Shichi et al (2011) Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. J.Pharmacol.Exp.Ther. 338 701. PMID: 21602423.

If you know of a relevant citation for this product please let us know.

Keywords: GM 6001, supplier, GM6001, matrix, metalloproteases, metalloproteinases, MMPs, broad-spectrum, inhibitors, inhibits, Ilomastat, Galardin

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