Cat. No. 1950
Biological ActivityPeptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC50 = 28.4 mM). Also inhibits IP3-induced ATP release, without inhibiting gap junctional coupling in endothelial cells.
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Certificate of Analysis / Safety Data Sheet
Chaytor et al (1997) Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J.Physiol. 503 99. PMID: 9288678.
Braet et al (2003) Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium 33 37. PMID: 12526886.
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Keywords: Gap 26, supplier, Gap, junction, blockers, connexin, 43, channels, modulators, Gap26