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[D-Arg¹,D-Phe⁵,D-Trp^7,9,Leu¹¹]-Substance P

Cat. No. 1946

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2

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Biological Activity

Broad spectrum neuropeptide antagonist/inverse agonist. Potent full inverse agonist for the ghrelin receptor (EC₅₀ = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.

Technical Data

M.Wt:

1516.85

Formula:

C₇₉H₁₀₉N₁₉O₁₂

Sequence:

RPKPFQWFWLL

(Modifications: Arg-1 = D-Arg, Phe-5 = D-Phe, Trp-7 = Trp-9 = D-Trp, Leu-11 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in 10% acetonitrile

Storage:

Desiccate at -20°C

CAS No:

96736-12-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Reeve and Bleehen (1994) [D-Arg¹, D-Phe⁵, D-Trp^7,9, Leu¹¹] Substance P induces apoptosis in lung cancer cells in vitro. Biochem.Biophys.Res.Commun. 199 1313. PMID: 7511895.

Jarpe et al (1998) [D-Arg¹, D-Phe⁵, D-Trp^7,9, Leu¹¹] Substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J.Biol.Chem. 273 3097. PMID: 9446627.

Holst et al (2003) High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist. Mol.Endocrinol. 17 2201. PMID: 12907757.

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Keywords: [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, supplier, Substance, P, broad, spectrum, neuropeptide, receptor, antagonists, inverse, agonists, Potent, ghrelin, Tachykinin, Neurokinin, Receptors, GHS-R1a, Growth, Hormone, Secretagog, Receptor, 1a, Ghrelin, [D-Arg1D-Phe5D-Trp79Leu11]-SubstanceP, neuropeptides

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