L-703,664 succinateCat No. 2640 |
Price and Availability |
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Chemical Name: N,N-Dimethyl-5-[(5-methyl-1,1-dioxodo-1,2,5-thiadiazoli din-2-yl)methyl]-1H-indole-3-ethanamine succinate |
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Biological Activity
5-HT1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50 values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D, 5-HT1A, 5-HT2A and 5-HT3 respectively) and other receptors (pIC50 < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors).Licensing Information
Sold with the permission of Merck, Sharpe and Dohme Ltd.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Castro et al (1994) Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor. J.Med.Chem. 37 3023.If you know of a useful citation for this product please let us know.
Keywords: L-703,664 succinate, Selective, 5-HT1D, receptor, agonists, Serotonin, Receptors
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