R&D Systems Inc. Tocris Bioscience Boston Biochem

L-703,664 succinate

Cat. No. 2640

L-703,664 succinate C16H24N4O2S.C4H6O4 [144776-01-2]

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Chemical Name: N,N-Dimethyl-5-[(5-methyl-1,1-dioxo­do-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indole-3-e­thanamine succinate

Biological Activity

5-HT1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50 values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D, 5-HT1A, 5-HT2A and 5-HT3 respectively) and other receptors (pIC50 < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors).

Licensing Information

Sold with the permission of Merck, Sharpe and Dohme Ltd.

Technical Data

M.Wt:
454.54
Formula:
C16H24N4O2S.C4H6O4
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
144776-01-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Castro et al (1994) Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor. J.Med.Chem. 37 3023. PMID: 7932524.

If you know of a relevant citation for this product please let us know.

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Keywords: L-703,664 succinate, supplier, Selective, 5-HT1D, receptor, agonists, Serotonin, Receptors, L703664

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