Cat. No. 2768
Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-m
Biological ActivityInsulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Anderson et al (2006) Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. J.Comb.Chem. 8 784. PMID: 16961415.
Gable et al (2006) Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol.Cancer 5 1079.
Sivakumar et al (2009) Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition. 34 329. PMID: 19148466.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PQ 401, supplier, IGF-IR, inhibitors, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, RTKs, PQ401, Insulin and Insulin-like Receptor Inhibitors
Find multiple products by catalog number
New Products in this Area
Potent VEGFR inhibitor; also aromatase inhibitorPF 06463922
High affinity and selective ALK and ROS1 inhibitor6bK
Insulin degrading enzyme (IDE) inhibitorCrizotinib
Potent c-MET/ALK inhibitor
December 15 - 17, 2015