Cat. No. 2768
Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
Biological ActivityInsulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Anderson et al (2006) Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. J.Comb.Chem. 8 784. PMID: 16961415.
Gable et al (2006) Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol.Cancer 5 1079.
Sivakumar et al (2009) Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition. 34 329. PMID: 19148466.
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Keywords: PQ 401, supplier, IGF-IR, inhibitors, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, RTKs, PQ401
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