Cat. No. 2768
Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-m
Biological ActivityInsulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Anderson et al (2006) Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. J.Comb.Chem. 8 784. PMID: 16961415.
Gable et al (2006) Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol.Cancer 5 1079.
Sivakumar et al (2009) Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition. 34 329. PMID: 19148466.
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Keywords: PQ 401, supplier, IGF-IR, inhibitors, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, RTKs, PQ401
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June 24 - 27, 2015
Booth Number: B11:25