PQ 401

Cat. No. 2768

PQ 401 C18H16ClN3O2 [196868-63-0]

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Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea

Biological Activity

Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.

Technical Data

M.Wt:
341.79
Formula:
C18H16ClN3O2
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
196868-63-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Anderson et al (2006) Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. J.Comb.Chem. 8 784. PMID: 16961415.

Gable et al (2006) Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol.Cancer 5 1079.

Sivakumar et al (2009) Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition. 34 329. PMID: 19148466.

If you know of a relevant citation for this product please let us know.

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Keywords: PQ 401, supplier, IGF-IR, inhibitors, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, RTKs, PQ401, Tocris Bioscience, Insulin and Insulin-like Receptor Inhibitors

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