Cat. No. 1941
Chemical Name: 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Biological ActivityActivator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate formation in a variety of cell types. Also inhibits growth of the leukemic cell lines U937 and THP-1. Inactive control o-3M3FBS (Cat. No. 1942) available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Bae et al (2003) Identification of a compound that directly stimulates phospholipase C activity. Mol.Pharmacol. 63 1043. PMID: 12695532.
Krjukova et al (2004) Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br.J.Pharmacol. 143 3. PMID: 15302681.
Lee et al (2005) The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 222 227. PMID: 15863272.
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Keywords: m-3M3FBS, supplier, Phospholipases, C, activators, activates, PLC, esterases