G-Protein antagonist peptide

Cat. No. 1931

G-Protein Antagonist peptide Glp-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2

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Alternative Name: GPAnt-2

Biological Activity

Substance P-related peptide that inhibits binding of G proteins to their receptors. Competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.

Technical Data


(Modifications: X = Glp, Trp-3 = Trp-5 = Trp-6 = D-Trp, Met-7 = C-terminal amide)

Soluble to 1 mg/ml in 50% acetonitrile / water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237. PMID: 1379592.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: G-Protein Antagonist peptide, supplier, inhibitors, G, protein, activation, by, GPCRs, Gi, Go, Gs, G-Protein, Heterotrimeric, antagonists, GPAnt2, substance, P

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