Signal Transduction
Stem Cells
Signaling Pathways
Product Type
All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
Caged Compounds
Fluorescent Probes
Screening Libraries
Ligand Sets
Other Product Types
Research Area
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-GluCat. No. 1927 |
Price and AvailabilityBy clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy. |
|
Chemical Name: N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid |
Biological Activity
Phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.Technical Data
M.Wt:(Modifications: Tyr-1 = pTyr with C-terminal Ac)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
References
Gilmer et al (1994) Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem. 269 31711. PMID: 7527393.
Pacofsky et al (1998) Potent dipeptide inhibitors of the pp60c-src SH2 domain. J.Med.Chem. 41 1894. PMID: 9599239.
Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711. PMID: 12217360.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu, supplier, Phosphopeptide, ligands, SH2, domain, Src, Kinases
Quick Order
Find multiple products by catalog number
Cancer Research Guide
Request your free copy
Highlights over 350 products for cancer research. Request a copy or view PDF today.
Kinases Product Listing
Highlights over 350 products for kinase research. Request a copy or view PDF today.
Kinase Inhibitor Toolbox
80 Kinase inhibitors
pre-dissolved in DMSO
Some of the most potent
kinase inhibitors all on one plate
Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.
Immunology Guide
Highlights over 150 products for immunology research. Request a copy or view PDF today.
New Products in this Area
Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
Flavopiridol hydrochlorideCyclin-dependent kinase inhibitor
GSK2578215APotent, selective LRRK2 inhibitor; brain penetrant
AmlexanoxInhibitor of TBK1 and IKKε; antiallergic agent
PF 05212384Potent and selective dual PI 3-kinase/mTOR inhibitor
PF 03814735Aurora kinase A and B inhibitor
PF 04691502Dual PI 3-K/mTOR inhibitor
TNPInhibitor of IP6K; also inhibits IP3K
ACHPSelective IKKα and IKKβ inhibitor
PD 0332991 isethionatePotent, selective Cdk4/6 inhibitor; brain penetrant
CZC 24832Selective inhibitor of PI 3-Kinase γ
LY 333531 hydrochlorideProtein kinase C inhibitor; selective for β isozymes
PF 06465469Potent inhibitor of interleukin-2 inducible T cell kinase (ITK). Also inhibits BTK
10Z-HymenialdisinePan kinase inhibitor; potently inhibits MEK-1
CP 690550 citratePotent JAK inhibitor
WYE 687 dihydrochloridePotent and selective mTOR inhibitor
N,N-DimethylsphingosineSphingosine kinase inhibitor
PEP 005Protein kinase C activator
CZC 54252 hydrochloridePotent LRRK2 inhibitor; neuroprotective
Bisindolylmaleimide IIPotent PKC inhibitor and nicotinic receptor antagonist
Tocris Events
Win a Kindle
British Cardiovascular Society Annual Conference 2013
June 3 - 5, 2013
London, UK
Booth Number: C54