Cat. No. 1927
Chemical Name: N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid
Biological ActivityPhosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.
(Modifications: Tyr-1 = pTyr with C-terminal Ac)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Gilmer et al (1994) Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem. 269 31711. PMID: 7527393.
Pacofsky et al (1998) Potent dipeptide inhibitors of the pp60c-src SH2 domain. J.Med.Chem. 41 1894. PMID: 9599239.
Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711. PMID: 12217360.
If you know of a relevant citation for this product please let us know.
Keywords: N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu, supplier, Phosphopeptide, ligands, SH2, domain, Src, Kinases
Find multiple products by catalog number
New Products in this Area
Potent inhibitor of Abl T315l mutant and wild-type Abl kinasesFlavopiridol hydrochloride
Cyclin-dependent kinase inhibitorGSK2578215A
Potent, selective LRRK2 inhibitor; brain penetrantAmlexanox
Inhibitor of TBK1 and IKKε; antiallergic agentPF 05212384
Potent and selective dual PI 3-kinase/mTOR inhibitorPF 03814735
Aurora kinase A and B inhibitorPF 04691502
Dual PI 3-K/mTOR inhibitorTNP
Inhibitor of IP6K; also inhibits IP3KACHP
Selective IKKα and IKKβ inhibitorPD 0332991 isethionate
Potent, selective Cdk4/6 inhibitor; brain penetrantCZC 24832
Selective inhibitor of PI 3-Kinase γLY 333531 hydrochloride
Protein kinase C inhibitor; selective for β isozymesPF 06465469
Potent inhibitor of interleukin-2 inducible T cell kinase (ITK). Also inhibits BTK10Z-Hymenialdisine
Pan kinase inhibitor; potently inhibits MEK-1CP 690550 citrate
Potent JAK inhibitorWYE 687 dihydrochloride
Potent and selective mTOR inhibitorN,N-Dimethylsphingosine
Sphingosine kinase inhibitorPEP 005
Protein kinase C activatorCZC 54252 hydrochloride
Potent LRRK2 inhibitor; neuroprotectiveBisindolylmaleimide II
Potent PKC inhibitor and nicotinic receptor antagonist
Win a Kindle
June 3 - 5, 2013
Booth Number: C54