Cat. No. 1899
Biological ActivityEndothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.
(Modifications: Disulfide bridge between 1 - 15, 3 - 11)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Minkes et al (1992) Comparison of responses to sarafotoxins 6a and 6c in pulmonary and systemic vascular beds. Am.J.Physiol. 262 H852. PMID: 1348398.
Schoeffter and Randriantsoa (1993) Differences between endothelial receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur.J.Pharmacol. 249 199. PMID: 8287901.
Raffa et al (1996) Endothelin-induced nociception in mice: mediation by ETA and ETB receptors. J.Pharmacol.Exp.Ther. 276 647. PMID: 8632332.
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Keywords: Sarafotoxin S6a, supplier, Endothelin, receptor, agonists, Non-Selective, ET, Receptors, SarafotoxinS6a
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October 5 - 8, 2014