R&D Systems Inc. Tocris Bioscience Boston Biochem

Sarafotoxin S6a

Cat. No. 1899

Sarafotoxin S6a Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridges: 1 - 15, 3 - 11)

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Biological Activity

Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.

Technical Data

M.Wt:
2514.85
Formula:
C105H156N28O34S5
Sequence:
CSCKDMTDKECLNFCHQDVIW

(Modifications: Disulfide bridge between 1 - 15, 3 - 11)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
126738-34-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Minkes et al (1992) Comparison of responses to sarafotoxins 6a and 6c in pulmonary and systemic vascular beds. Am.J.Physiol. 262 H852. PMID: 1348398.

Schoeffter and Randriantsoa (1993) Differences between endothelial receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur.J.Pharmacol. 249 199. PMID: 8287901.

Raffa et al (1996) Endothelin-induced nociception in mice: mediation by ETA and ETB receptors. J.Pharmacol.Exp.Ther. 276 647. PMID: 8632332.

If you know of a relevant citation for this product please let us know.

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Keywords: Sarafotoxin S6a, supplier, Endothelin, receptor, agonists, Non-Selective, ET, Receptors, SarafotoxinS6a

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