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Neuropeptide SF (human)

Cat. No. 1886

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Alternative Name: Neuropeptide NPFF (human FMRFamide-related)

Biological Activity

Endogenous antiopioid peptide, implicated in pain modulation and endocrine functions. Potently activates the orphan G-protein-coupled receptor HLWAR77 (NPFF₂) (EC₅₀ = 0.39 nM).

Technical Data

M.Wt:

1367.57

Formula:

C₆₅H₉₄N₁₈O₁₅

Sequence:

SQAFLFQPQRF

(Modifications: Phe-11 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in 10% acetonitrile / water

Storage:

Desiccate at -20°C

CAS No:

192387-39-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Elshourbagy et al (2000) Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J.Biol.Chem. 275 25965. PMID: 10851242.

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Keywords: Neuropeptide SF (human), supplier, Implicated, pain, modulation, Anti-opioids, NPFF, Receptors, Neuropeptides, FF/AF, HLWAR77, NPFFR2, NeuropeptideSF, (human), npff2, neuropeptide

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7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy