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U 46619

Cat No. 1932

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Alternative Name: 9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F_2a

Chemical Name: (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2 -oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid

Biological Activity

PGH₂ (TXA₂) analog that is a potent and stable thromboxane A₂ (TP) receptor agonist (EC₅₀ = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK-293 cells expressing TPα and TPβ receptors.

Technical Data

M.Wt:

350.5

Formula:

C₂₁H₃₄O₄

Solubility:

Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

[56985-40-1]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

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Material Safety Data Sheet: View current batch

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References

Coleman et al (1981) Comparison of the actions of U-46619, a prostaglandin H₂-analogue, with those of prostaglandin H₂ and thromboxane A₂ on some isolated smooth muscle preparations. Br.J.Pharmacol. 73 773. Morinelli et al (1987) Receptor-mediated effects of a PGH₂ analogue (U 46619) on human platelets. Am.J.Physiol. 253 H1035. Miggin and Kinsella (2002) Regulation of extracellular signal-regulated kinase cascades by a- and b-isoforms of the human thromboxane A₂ receptor. Mol.Pharmacol. 61 817.

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Prostanoid Receptors

Keywords: U 46619, Potent, stable, thromboxane, A2, TP, receptor, agonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, U46619, 9, 11-Dideoxy-9a, 11a-methanoepoxy, prostaglandinF2a

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