BTS

Cat. No. 1870

BTS C14H15NO2S [1576-37-0]

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Chemical Name: 4-Methyl-N-(phenylmethyl)benzenesulfonamide

Biological Activity

Selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.

Technical Data

M.Wt:
261.34
Formula:
C14H15NO2S
Solubility:
Soluble to 70 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1576-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Cheung et al (2001) A small-molecule inhibitor of skeletal muscle myosin II. Nat.Cell.Biol. 4 83. PMID: 11744924.

Ramachandran et al (2003) Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis. Cell Motil.Cytoskeleton 55 61. PMID: 12673599.

Shaw et al (2003) Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry 42 6128. PMID: 12755615.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: BTS, supplier, Selective, inhibitors, skeletal, muscle, myosin, II, ATPase, activity

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