R&D Systems Inc. Tocris Bioscience Boston Biochem

BTS

Cat. No. 1870

BTS C14H15NO2S [1576-37-0]

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Chemical Name: 4-Methyl-N-(phenylmethyl)benzenesulfonamide

Biological Activity

Selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.

Technical Data

M.Wt:
261.34
Formula:
C14H15NO2S
Solubility:
Soluble to 70 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1576-37-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Cheung et al (2001) A small-molecule inhibitor of skeletal muscle myosin II. Nat.Cell.Biol. 4 83. PMID: 11744924.

Ramachandran et al (2003) Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis. Cell Motil.Cytoskeleton 55 61. PMID: 12673599.

Shaw et al (2003) Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry 42 6128. PMID: 12755615.

If you know of a relevant citation for this product please let us know.

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Keywords: BTS, supplier, Selective, inhibitors, skeletal, muscle, myosin, II, ATPase, activity

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