Ro 60-0175 fumarate

Cat. No. 1854

Ro 60-0175 C11H12ClFN2.C4H4O4 [169675-09-6]

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Chemical Name: (αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine fumarate

Biological Activity

Potent, selective 5-HT2 receptor agonist; shows selectivity for the 5-HT2C subtype (pKi values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo.

Technical Data

M.Wt:
342.75
Formula:
C11H12ClFN2.C4H4O4
Solubility:
Soluble to 5 mM in water and to 20 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
169675-09-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Martin et al (1998) 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. J.Pharmacol.Exp.Ther. 286 913. PMID: 9694950.

Kennett et al (2000) Effects of Ro 60 0175, a 5-HT2C receptor agonist, in three animal models of anxiety. Eur.J.Pharmacol. 387 197. PMID: 10650160.

Damjanoska et al (2003) Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine2C receptor agonist. J.Pharmacol.Exp.Ther. 304 1209. PMID: 12604698.

Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive properties. J.Med.Chem. 56 1211. PMID: 23301527.

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Keywords: Ro 60-0175, supplier, Potent, selective, 5-HT2C, agonists, Serotonin, Receptors, Ro60-0175

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