R&D Systems Inc. Tocris Bioscience Boston Biochem

Ro 60-0175 fumarate

Cat. No. 1854

Ro 60-0175 C11H12ClFN2.C4H4O4 [169675-09-6]

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Chemical Name: (αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine fumarate

Biological Activity

Potent, selective 5-HT2 receptor agonist; shows selectivity for the 5-HT2C subtype (pKi values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo.

Technical Data

M.Wt:
342.75
Formula:
C11H12ClFN2.C4H4O4
Solubility:
Soluble to 5 mM in water and to 20 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
169675-09-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Martin et al (1998) 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. J.Pharmacol.Exp.Ther. 286 913. PMID: 9694950.

Kennett et al (2000) Effects of Ro 60 0175, a 5-HT2C receptor agonist, in three animal models of anxiety. Eur.J.Pharmacol. 387 197. PMID: 10650160.

Damjanoska et al (2003) Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine2C receptor agonist. J.Pharmacol.Exp.Ther. 304 1209. PMID: 12604698.

Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive properties. J.Med.Chem. 56 1211. PMID: 23301527.

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Keywords: Ro 60-0175, supplier, Potent, selective, 5-HT2C, agonists, Serotonin, Receptors, Ro60-0175

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