Glucagon-like peptide 1 (1-37) (human, rat)
Cat. No. 1851
Alternative Name: GLP-1 (1-37) amide
Biological ActivityPancreatic hormone synthesized by post-translational processing of proglucagon. Unlike truncated forms of GLP-1, it has no effect on food intake in rats and does not enhance pancreatic insulin secretion. However it induces insulin expression in intestinal epithelial cells, which can restore glucose homeostasis when implanted into diabetic mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Bell et al (1983) Exon duplication and divergence in the human preproglucagon gene. Nature 304 368. PMID: 6877358.
Navarro et al (1996) Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J.Neurochem. 67 1982. PMID: 8863504.
Suzuki et al (2003) Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells. Proc.Natl.Acad.Sci.USA 100 5034.
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