R&D Systems Inc. Tocris Bioscience Boston Biochem

Ac2-12

Cat. No. 1846

Ac2-12 Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp

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Biological Activity

Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.

Licensing Information

Sold under license from The William Harvey Research Institute

Technical Data

M.Wt:
1351.58
Formula:
C63H94N14O17S
Sequence:
AMVSEFLKQAW

(Modifications: Ala-1 = N-terminal Ac)

Solubility:
Soluble to 1 mg/ml in 20% acetonitrile / water
Storage:
Desiccate at -20°C
CAS No:
256447-08-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1 Proc.Natl.Acad.Sci.U.S.A. 95 14535. PMID: 9826735.

Perretti et al (2001) Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am.J.Pathol. 158 1969. PMID: 11395373.

If you know of a relevant citation for this product please let us know.

Keywords: Ac2-12, supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules

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