Cat. No. 1846

Ac2-12 Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp

Price and Availability

For Ac2-12 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.

Licensing Information

Sold under license from The William Harvey Research Institute

Technical Data


(Modifications: Ala-1 = N-terminal Ac)

Soluble to 1 mg/ml in 20% acetonitrile / water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1 Proc.Natl.Acad.Sci.U.S.A. 95 14535. PMID: 9826735.

Perretti et al (2001) Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am.J.Pathol. 158 1969. PMID: 11395373.

If you know of a relevant citation for this product please let us know.

Keywords: Ac2-12, supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide


Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

divider line

Bio-Techne Events

Pharmacology 2015

Pharmacology 2015

December 15 - 17, 2015

London UK