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Ac2-26

Cat. No. 1845

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Biological Activity

Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo. Anti-inflammatory.

Licensing Information

Sold under license from The William Harvey Research Institute

Technical Data

M.Wt:

3089.46

Formula:

C₁₄₁H₂₁₀N₃₂O₄₄S

Sequence:

AMVSEFLKQAWFIENEEQEYVQTVK

(Modifications: Ala-1 = N-terminal Ac)

Solubility:

Soluble to 1 mg/ml in 20% acetonitrile / 0.25% NH4OH

Storage:

Desiccate at -20°C

CAS No:

151988-33-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Perretti et al (1993) Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J.Immunol. 151 4306. PMID: 8409403.

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc.Natl.Acad.Sci.U.S.A. 95 14535. PMID: 9826735.

Perretti and Gavins (2003) Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. 18 60. PMID: 12644621.

If you know of a relevant citation for this product please let us know.

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