R&D Systems Inc. Tocris Bioscience Boston Biochem

Ac2-26

Cat. No. 1845

Ac2-26 Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys

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Biological Activity

Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo. Anti-inflammatory.

Licensing Information

Sold under license from The William Harvey Research Institute

Technical Data

M.Wt:
3089.46
Formula:
C141H210N32O44S
Sequence:
AMVSEFLKQAWFIENEEQEYVQTVK

(Modifications: Ala-1 = N-terminal Ac)

Solubility:
Soluble to 1 mg/ml in PBS
Storage:
Desiccate at -20°C
CAS No:
151988-33-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Perretti et al (1993) Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J.Immunol. 151 4306. PMID: 8409403.

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc.Natl.Acad.Sci.U.S.A. 95 14535. PMID: 9826735.

Perretti and Gavins (2003) Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. 18 60. PMID: 12644621.

If you know of a relevant citation for this product please let us know.

Keywords: Ac2-26, supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules

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