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BIM 23056

Cat. No. 1844

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Biological Activity

Somatostatin receptor ligand (K_i values are 142, > 1000, 10.8, 16.6 and 5.7 nM for human cloned sst_{1 - 5} receptors respectively). Behaves as an antagonist on SRIF14-induced [³⁵S]-GTPγS binding at sst₃ and sst₅ receptors (PK_B values are 6.33 and 5.84 respectively).

Technical Data

M.Wt:

1232.49

Formula:

C₇₁H₈₁N₁₁O₉

Sequence:

FFYWKVFX

(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X = D-Nal & C-terminal amide)

Solubility:

Soluble to 1 mg/ml in 20% acetonitrile / water

Storage:

Desiccate at -20°C

CAS No:

150155-61-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Mol.Pharmacol. 43 838. PMID: 8100350.

Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814. PMID: 7988476.

Wilkinson et al (1996) Potent antagonism by BIM-23056 at the human recombinant somatostatin sst₅ receptor. Br.J.Pharmacol. 118 445. PMID: 8762063.

Siehler and Hoyer (1999) Characterisation of human recombinant somatostatin receptors. Modulation of GTPgammaS binding. Naunyn Schmiedebergs Arch.Pharmacol. 360 500. PMID: 10598789.

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