R&D Systems Inc. Tocris Bioscience Boston Biochem

Fostriecin sodium salt

Cat. No. 1840

Fostriecin sodium salt C19H26O9PNa [87860-39-7]

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Chemical Name: (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt

Biological Activity

Originally identified as an antitumor antibiotic from Streptomyces pulveraceous. Displays potent inhibition of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo.

Technical Data

M.Wt:
452.37
Formula:
C19H26O9PNa
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
87860-39-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Tunac et al (1983) Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties. J.Antibiot. 36 1595. PMID: 6689323.

Walsh et al (1997) Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett. 416 230. PMID: 9373158.

Hastie and Cohen (1998) Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Lett. 431 357. PMID: 9714542.

If you know of a relevant citation for this product please let us know.

Keywords: Fostriecin sodium salt, supplier, Potent, PP2A, PP4, inhibitors, Calcineurin, Protein, Ser/Thr, protein, phosphatases, 2A, 4, antibiotics

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