Fostriecin sodium salt
Cat. No. 1840
Chemical Name: (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z
Biological ActivityOriginally identified as an antitumor antibiotic from Streptomyces pulveraceous. Displays potent inhibition of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo.
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Certificate of Analysis / Safety Data Sheet
Tunac et al (1983) Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties. J.Antibiot. 36 1595. PMID: 6689323.
Walsh et al (1997) Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett. 416 230. PMID: 9373158.
Hastie and Cohen (1998) Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Lett. 431 357. PMID: 9714542.
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Keywords: Fostriecin sodium salt, supplier, Potent, PP2A, PP4, inhibitors, Calcineurin, Protein, Ser/Thr, protein, phosphatases, 2A, 4, antibiotics