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HS 024

Cat. No. 1832

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Biological Activity

Highly potent melanocortin MC₄ receptor antagonist (K_i values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC₄, MC₁, MC₃ and MC₅ receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.

Technical Data

M.Wt:

1266.5

Formula:

C₅₈H₇₉N₁₉O₁₀S₂

Sequence:

CXRHXRWGC

(Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge between 1 - 9)

Solubility:

Soluble to 0.50 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

212370-59-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Kask et al (1998) Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 139 5006. PMID: 9832440.

Jonsson et al (2001) Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 12 3703. PMID: 11726778.

Jonsson et al (2002) Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J.Endocrinol. 173 517. PMID: 12065241.

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