R&D Systems Inc. Tocris Bioscience Boston Biochem

Palmitoylisopropylamide

Cat. No. 1815

Palmitoylisopropylamide C19H39NO [189939-61-5]

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Alternative Name: PIA

Chemical Name: N-(1-Methylethyl)-hexadecanamide

Biological Activity

Inhibitor of fatty acid amide hydrolase (FAAH); pIC50 = 4.89 for inhibition of [3H]-anandamide metabolism. Displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Inhibits proliferation of C6 glioma cells.

Technical Data

M.Wt:
297.52
Formula:
C19H39NO
Solubility:
Soluble to 100 mM in ethanol and to 10 mM in DMSO
Storage:
Store at RT
CAS No:
189939-61-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Jonsson et al (2001) Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. Br.J.Pharmacol. 133 1263. PMID: 11498512.

Jonsson et al (2003) AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch.Toxicol. 77 201. PMID: 12698235.

If you know of a relevant citation for this product please let us know.

Keywords: Palmitoylisopropylamide, supplier, inhibitors, FAAH, cannabinoids, Receptors, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases

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