Palmitoylisopropylamide

Cat. No. 1815

Palmitoylisopropylamide C19H39NO [189939-61-5]

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Alternative Name: PIA

Chemical Name: N-(1-Methylethyl)-hexadecanamide

Biological Activity

Inhibitor of fatty acid amide hydrolase (FAAH); pIC50 = 4.89 for inhibition of [3H]-anandamide metabolism. Displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Inhibits proliferation of C6 glioma cells.

Technical Data

M.Wt:
297.52
Formula:
C19H39NO
Solubility:
Soluble to 100 mM in ethanol and to 10 mM in DMSO
Storage:
Store at RT
CAS No:
189939-61-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Jonsson et al (2001) Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. Br.J.Pharmacol. 133 1263. PMID: 11498512.

Jonsson et al (2003) AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch.Toxicol. 77 201. PMID: 12698235.

If you know of a relevant citation for this product please let us know.

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Keywords: Palmitoylisopropylamide, supplier, inhibitors, FAAH, cannabinoids, Receptors, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, Tocris Bioscience, Other Cannabinoid Inhibitors

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