Cat. No. 1813
Alternative Name: Indirubin-3'-monoxime
Chemical Name: 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Biological ActivityProtein kinase inhibitor; inhibits cyclin-dependent kinases (IC50 = 0.18 - 3.33 μM) and GSK-3β (IC50 = 0.19 μM). Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Hoessel et al (1999) Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat.Cell.Biol. 1 60. PMID: 10559866.
Leclerc et al (2001) Indirubins inhibit glycogen synthase kinase-3β and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. J.Biol.Chem. 276 251. PMID: 11013232.
Bain et al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199. PMID: 12534346.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Indirubin-3'-oxime, supplier, Protein, kinase, GSK-3β, GSK-3beta, inhibits, inhibitors, kinases, Cyclin-dependent, Induces, cell, cycle, arrest, antiproliferative, Broad, Spectrum, GSK, Glycogen, Synthase, 3, Cdk, Cyclin-Dependent, Carbohydrate, Metabolism, Cell, Cycle, Indirubin-3-oxime, Indirubin-3-monoxime
Find multiple products by catalog number
New Products in this Area
Potent inhibitor of Abl T315l mutant and wild-type Abl kinasesFlavopiridol hydrochloride
Cyclin-dependent kinase inhibitorGSK2578215A
Potent, selective LRRK2 inhibitor; brain penetrantAmlexanox
Inhibitor of TBK1 and IKKε; antiallergic agentPF 05212384
Potent and selective dual PI 3-kinase/mTOR inhibitorPF 03814735
Aurora kinase A and B inhibitorPF 04691502
Dual PI 3-K/mTOR inhibitorTNP
Inhibitor of IP6K; also inhibits IP3KACHP
Selective IKKα and IKKβ inhibitorPD 0332991 isethionate
Potent, selective Cdk4/6 inhibitor; brain penetrantCZC 24832
Selective inhibitor of PI 3-Kinase γLY 333531 hydrochloride
Protein kinase C inhibitor; selective for β isozymesPF 06465469
Potent inhibitor of interleukin-2 inducible T cell kinase (ITK). Also inhibits BTK10Z-Hymenialdisine
Pan kinase inhibitor; potently inhibits MEK-1CP 690550 citrate
Potent JAK inhibitorWYE 687 dihydrochloride
Potent and selective mTOR inhibitorN,N-Dimethylsphingosine
Sphingosine kinase inhibitorPEP 005
Protein kinase C activatorCZC 54252 hydrochloride
Potent LRRK2 inhibitor; neuroprotectiveBisindolylmaleimide II
Potent PKC inhibitor and nicotinic receptor antagonist
Win a Kindle
June 15 - 18, 2013
San Francisco, CA
Booth Number: 1032