Cat. No. 1813
Alternative Name: Indirubin-3'-monoxime
Chemical Name: 3-[1,3-Dihydro-3-(hydroxyimino)-2H-
Biological ActivityProtein kinase inhibitor; inhibits cyclin-dependent kinases (IC50 = 0.18 - 3.33 μM) and GSK-3β (IC50 = 0.19 μM). Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Hoessel et al (1999) Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat.Cell.Biol. 1 60. PMID: 10559866.
Leclerc et al (2001) Indirubins inhibit glycogen synthase kinase-3β and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. J.Biol.Chem. 276 251. PMID: 11013232.
Bain et al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199. PMID: 12534346.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Indirubin-3'-oxime, supplier, Protein, kinase, GSK-3β, GSK-3beta, inhibits, inhibitors, kinases, Cyclin-dependent, Induces, cell, cycle, arrest, antiproliferative, Broad, Spectrum, GSK, Glycogen, Synthase, 3, Cdk, Cyclin-Dependent, Carbohydrate, Metabolism, Cell, Cycle, Indirubin-3-oxime, Indirubin-3-monoxime, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitors
Find multiple products by catalog number
New Products in this Area
PKC activator; also NF-κB activatorTBCA
Selective CK2 inhibitorMSC 2032964A
Potent and selective ASK1 inhibitor; orally bioavailableCW 008
PKA signaling activator; promotes osteogenesis from hMSCsPF 06447475
Potent LRRK2 inhibitor; neuroprotectiveAMG PERK 44
Potent and selective PERK inhibitor; orally bioavailableCGP 60474
Potent dual cdk1/cdk2 inhibitorCGP 74514 dihydrochloride
Potent cdk1 inhibitorKG 5
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitorNilvadipine
Syk kinase inhibitor; inhibits Aβ productionCentrinone B
High affinity and selective PLK4 inhibitorHTH 01-015
Potent and selective NUAK1 inhibitorKobe 0065
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signalingOSU 03012
PDK1 inhibitor; inhibits Akt signalingSR 7826
Potent and selective LIMK inhibitor; antitumorMps BAY 2a
Potent and selective Mps1 kinase inhibitorNG 25
TGF-β-activated kinase (TAK1) inhibitorMI 14
Potent and selective PI 4-kinase IIIβ inhibitorCTA 056
ITK inhibitorAZD 1480
Potent and selective JAK2 inhibitor; antiangiogenicTC-S 7001
Potent and highly selective ROCK inhibitor; orally activeAS 2444697
Potent and selective IRAK4 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.