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Decanoyl-RVKR-CMK

Cat. No. 3501

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Biological Activity

Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.

Technical Data

M.Wt:

744.42

Formula:

C₃₄H₆₆ClN₁₁O₅

Sequence:

RVKR

(Modifications: Arg-1 = Decanoyl-Arg, Arg-4 = chlororomethylketone)

Solubility:

Soluble to 1 mg/ml in water

Storage:

Store at -20°C

CAS No:

150113-99-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Denault et al (1995) Inhibition of convertase-related processing of proendothelin-1. J.Cardiovasc.Pharmacol. 26 S47. PMID: 8587448.

Garcia et al (2005) A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J.Biol.Chem. 280 41595. PMID: 16221685.

Tian and Jianhua (2010) Comparative study of the binding pocket of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors. Int.J.Biol.Sci. 6 89. PMID: 20151049.

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Proteases

Keywords: Decanoyl-RVKR-CMK, supplier, proprotein, convertases, inhibitors, inhibits, supplier, proteolytic, cleavage, calcium, dependent, serine, endopeptidases, furin, PC1, PC2, PC4, PACE4, PC5, PC7, secretory, pathway