R&D Systems Inc. Tocris Bioscience Boston Biochem

VULM 1457

Cat. No. 2988

VULM 1457 C25H27N3O3S [228544-65-8]

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Chemical Name: N-[2,6-bis(1-Methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea

Biological Activity

Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. Decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolemic rats.

Technical Data

M.Wt:
449.57
Formula:
C25H27N3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
228544-65-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Adameova et al (2006) Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats. Pharmazie 61 807. PMID: 17020164.

Adameova et al (2007) The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA: cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in vivo. Eur.J.Pharmacol. 576 114. PMID: 17764671.

Vojtassakova et al (2007) Effect of VULM 1457, an ACAT inhibitor, on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet. Gen.Physiol.Biophys. 26 254. PMID: 18281742.

If you know of a relevant citation for this product please let us know.

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Keywords: VULM 1457, supplier, Acyl-CoA, cholesterol, acyltransferase, ACAT, inhibitors, Transferases, VULM1457

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