VULM 1457

Cat. No. 2988

VULM 1457 C25H27N3O3S [228544-65-8]

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Chemical Name: N-[2,6-bis(1-Methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea

Biological Activity

Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. Decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolemic rats.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Adameova et al (2006) Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats. Pharmazie 61 807. PMID: 17020164.

Adameova et al (2007) The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA: cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in vivo. Eur.J.Pharmacol. 576 114. PMID: 17764671.

Vojtassakova et al (2007) Effect of VULM 1457, an ACAT inhibitor, on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet. Gen.Physiol.Biophys. 26 254. PMID: 18281742.

If you know of a relevant citation for this product please let us know.

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Keywords: VULM 1457, supplier, Acyl-CoA, cholesterol, acyltransferase, ACAT, inhibitors, Transferases, VULM1457, Acyl-CoA:Cholesterol Acyltransferase Inhibitors

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