R&D Systems Inc. Tocris Bioscience Boston Biochem

VULM 1457

Cat. No. 2988

VULM 1457 C25H27N3O3S [228544-65-8]

Price and Availability

For VULM 1457 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[2,6-bis(1-Methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea

Biological Activity

Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. Decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolemic rats.

Technical Data

M.Wt:
449.57
Formula:
C25H27N3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
228544-65-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Adameova et al (2006) Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats. Pharmazie 61 807. PMID: 17020164.

Adameova et al (2007) The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA: cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in vivo. Eur.J.Pharmacol. 576 114. PMID: 17764671.

Vojtassakova et al (2007) Effect of VULM 1457, an ACAT inhibitor, on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet. Gen.Physiol.Biophys. 26 254. PMID: 18281742.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: VULM 1457, supplier, Acyl-CoA, cholesterol, acyltransferase, ACAT, inhibitors, Transferases, VULM1457

Quick Order

Find multiple products by catalog number

divider line

New Product E-alerts

Sign up for email updates from Tocris

e-alerts

Enter your email address below to sign up to receive our email updates:

divider line

New Products in this Area

XY1

Negative control of SGC 707 (Cat. No. 5367)

SGC 707

Potent and selective allosteric inhibitor of PRMT3

IWP 12

Potent PORCN inhibitor; active in vivo

AZD 3988

Potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitor

WDR5 0103

WDR5 antagonist

UNC 2400

Negative control of UNC 1999 (Cat. No. 4904)

UNC 1999

Potent and selective EZH2/EZH1 histone lysine methyltransferase inhibitor

Garcinol

PCAF/p300 HAT inhibitor; anticancer

(S)-PFI 2 hydrochloride

Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)

Sign-up for new product e-alerts
divider line

Bio-Techne Events

DPG 2015

Experimental Biology 2015

March 28 - April 1, 2015

Boston, MA

Booth: 456