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Gabexate mesylate

Cat. No. 1798

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Alternative Name: FOY

Chemical Name: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate

Biological Activity

Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC₅₀ values are 9.4, 30, 41 and 110 μM respectively). Antithrombotic in vitro and in vivo. Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation.

Technical Data

M.Wt:

417.48

Formula:

C₁₆H₂₃N₃O₄.CH₃SO₃H

Solubility:

Soluble to 100 mM in water

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

39492-01-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Tamura et al (1977) Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C_1r and C₁ esterase. Biochim.Biophys.Acta 484 417. PMID: 143965.

Ohno et al (1980) FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro. Thromb.Res. 19 579. PMID: 6449757.

Ohno et al (1981) FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. II. In vivo effect on coagulo-fibrinolytic system in comparison with heparin or aprotinin. Thromb.Res. 24 445. PMID: 6178174.

Yuksel et al (2003) Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α production by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytes. J.Pharmacol.Exp.Ther. 305 298. PMID: 12649382.

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