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5-Oxo-ETE

Cat. No. 1796

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Alternative Name: 5-KETE

Chemical Name: 5-Oxo-(6E,8Z,11Z,14Z)-6,8,11,14-eicosatetraenoic acid

Biological Activity

Potent oxoeicosanoid (OXE) receptor agonist (EC₅₀ = 0.33 nM). Chemoattractant for both neutrophils and eosinophils and induces transendothelial migration of eosinophils.

Technical Data

M.Wt:

318.46

Formula:

C₂₀H₃₀O₃

Solubility:

Soluble in ethanol (supplied pre-dissolved in Ethanol, 0.1mg/ml)

Purity:

>95 %

Storage:

Store at -80°C

CAS No:

106154-18-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Powell et al (1994) Effects of phorbol myristate acetate on the synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human polymorphonuclear leukocytes. Biochemistry 33 3927. PMID: 8142396.

Jones et al (2003) Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. Mol.Pharmacol. 63 471. PMID: 12606753.

Patel et al (2008) Structural requirements for activation of the 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor: identification of a mead acid metabolite with potent agonist activity. J.Pharmacol.Exp.Ther. 325 698. PMID: 18292294.

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Keywords: 5-oxo-ETE, supplier, Oxoeicosanoid, receptor, agonists, Receptors, leukotrienes, eicosanoids

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