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Ro 26-4550 trifluoroacetate

Cat. No. 1794

Ro 26-4550 C26H30N4O3.CF3CO2H [193744-04-6]

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Chemical Name: N-[[(3R)-1-(Aminoiminomethyl)-3-piperidinyl]acetyl]-4-(phenylethynyl)-L-phenylalanine methyl ester trifluoroacetate

Biological Activity

Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC₅₀ = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.

Technical Data

M.Wt:

560.57

Formula:

C₂₆H₃₀N₄O₃.CF₃CO₂H

Solubility:

Soluble to 50 mM in DMSO and to 5 mM in ethanol

Purity:

>98 %

Storage:

Desiccate at +4°C

CAS No:

193744-04-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Tilley et al (1997) Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2. J.Am.Chem.Soc. 119 7589.

Braisted et al (2003) Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J.Am.Chem.Soc. 125 3714. PMID: 12656598.

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