Ro 26-4550 trifluoroacetate
Cat. No. 1794
Chemical Name: N-[[(3R)-1-(Aminoiminomethyl)-3-pip
Biological ActivityCompetitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Tilley et al (1997) Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2. J.Am.Chem.Soc. 119 7589.
Braisted et al (2003) Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J.Am.Chem.Soc. 125 3714. PMID: 12656598.
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Keywords: Ro 26-4550 trifluoroacetate, supplier, Competitive, inhibitors, IL-2/, IL-2Ralpha, interaction, IL, Receptors, Interleukins, Cytokines, Ro26-4550
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