R&D Systems Inc. Tocris Bioscience Boston Biochem

Ro 26-4550 trifluoroacetate

Cat. No. 1794

Ro 26-4550 trifluoroacetate C26H30N4O3.CF3CO2H [1217448-66-2]

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Chemical Name: N-[[(3R)-1-(Aminoiminomethyl)-3-piperidinyl]acetyl]-4-(phenylethynyl)-L-phenylalanine methyl ester trifluoroacetate

Biological Activity

Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.

Technical Data

M.Wt:
560.57
Formula:
C26H30N4O3.CF3CO2H
Solubility:
Soluble to 50 mM in DMSO and to 5 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
1217448-66-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Tilley et al (1997) Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2. J.Am.Chem.Soc. 119 7589.

Braisted et al (2003) Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J.Am.Chem.Soc. 125 3714. PMID: 12656598.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Ro 26-4550 trifluoroacetate, supplier, Competitive, inhibitors, IL-2/, IL-2Ralpha, interaction, IL, Receptors, Interleukins, Cytokines, Ro26-4550

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