Ro 26-4550 trifluoroacetate

Cat. No. 1794

Ro 26-4550 trifluoroacetate C26H30N4O3.CF3CO2H [1217448-66-2]

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Chemical Name: N-[[(3R)-1-(Aminoiminomethyl)-3-piperidinyl]acetyl]-4-(phenylethynyl)-L-phenylalanine methyl ester trifluoroacetate

Biological Activity

Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.

Technical Data

Soluble to 50 mM in DMSO and to 5 mM in ethanol
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Tilley et al (1997) Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2. J.Am.Chem.Soc. 119 7589.

Braisted et al (2003) Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J.Am.Chem.Soc. 125 3714. PMID: 12656598.

If you know of a relevant citation for this product please let us know.

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Keywords: Ro 26-4550 trifluoroacetate, supplier, Competitive, inhibitors, IL-2/, IL-2Ralpha, interaction, IL, Receptors, Interleukins, Cytokines, Ro26-4550

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