Home » Research Area » » Enzymes » Kinases » Protein Kinase C » PKC ζ pseudosubstrate

PKC ζ pseudosubstrate

Cat. No. 1791

PKC z pseudosubstrate H-Cys-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH H-Cys-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-Tyr-Arg-Ala-Asn-OH

Price and Availability

For PKC ζ pseudosubstrate pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Protein kinase C zeta pseudosubstrate

Biological Activity

Inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.

Technical Data

M.Wt:

4673.59

Formula:

C₂₀₈H₃₃₆N₇₄O₄₄S₃

Sequence:

CRQIKIWFQNRRMKWKK CSIYRRGARRWRKLYRAN*

(Modifications: Disulfide bridge between 1 -1*)

Solubility:

Soluble to 2 mg/ml in 30% acetonitrile / water

Storage:

Store at -20°C

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158. PMID: 7472470.

Laudanna et al (1998) Evidence of ζ protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J.Biol.Chem 273 30306. PMID: 9804792.

Lim et al (2008) A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity. Life Sci. 82 733. PMID: 18289606.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Kinases

Protein Kinase C

Keywords: PKC z pseudosubstrate, supplier, PKC, zeta, inhibitors, Protein, Kinases, C, pseudosubstrate, PKCz, ProteinkinaseC

Quick Order

Find multiple products by catalog number

Cancer Research Guide

Request your free copy

Highlights over 350 products for cancer research. Request a copy or view PDF today.

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

Pain Research Guide

Reserve your free copy

Highlights over 280 products for Pain research. Reserve copy

Calcium Imbalance and Neuroprotective Targets

Written by E. Besancon et al

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.