R&D Systems Inc. Tocris Bioscience Boston Biochem

Dynamin inhibitory peptide

Cat. No. 1774

Dynamin inhibitory peptide Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro

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Alternative Name: P4

Biological Activity

Peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors. Cell-permeable version also available (Cat. No. 1775).

Technical Data

M.Wt:
1121.26
Formula:
C47H80N18O14
Sequence:
QVPSRPNRAP
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
251634-21-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419. PMID: 9148966.

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972. PMID: 11050117.

Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302. PMID: 12646920.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Dynamin inhibitory peptide, supplier, Dynamin, inhibitors, Mitosis, Epac, GTPases

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