Dynamin inhibitory peptide

Cat. No. 1774

Dynamin inhibitory peptide Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro

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Alternative Name: P4

Biological Activity

Peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors. Cell-permeable version also available (Cat. No. 1775).

Technical Data

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419. PMID: 9148966.

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972. PMID: 11050117.

Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302. PMID: 12646920.

If you know of a relevant citation for this product please let us know.

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Keywords: Dynamin inhibitory peptide, supplier, Dynamin, inhibitors, Mitosis, Epac, GTPases, GTPase Inhibitors

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