Fumagillin

Cat. No. 1768

Fumagillin C26H34O7 [23110-15-8]

Price and Availability

For Fumagillin pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester

Biological Activity

Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice. Analog available, TNP 470 (Cat.No. 3750).

Technical Data

M.Wt:
458.55
Formula:
C26H34O7
Solubility:
Soluble to 3 mM in ethanol
Storage:
Store at -20°C
CAS No:
23110-15-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327. PMID: 4630977.

Ingber et al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555. PMID: 1701033.

Lowther et al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153. PMID: 9770455.

Rodriguez-Nieto et al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457. PMID: 11848509.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: Fumagillin, supplier, Methionine, aminopeptidase-2, inhibitors, Proteases, Proteinases, antiangiogenics, angiogenesis, antibiotics, Tocris Bioscience, Aminopeptidase Inhibitors

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

NPG

Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

VTP 27999 trifluoroacetate

Highly potent and selective renin inhibitor

Tiplaxtinin

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Balicatib

Potent and selective cathepsin K inhibitor

HFI 142

Insulin-regulated aminopeptidase (IRAP) inhibitor

SSM 3 trifluoroacetate

Potent furin inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.