R&D Systems Inc. Tocris Bioscience Boston Biochem

Fumagillin

Cat. No. 1768

Fumagillin C26H34O7 [23110-15-8]

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Chemical Name: (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester

Biological Activity

Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice. Analog available, TNP 470 (Cat.No. 3750).

Technical Data

M.Wt:
458.55
Formula:
C26H34O7
Solubility:
Soluble to 3 mM in ethanol
Storage:
Store at -20°C
CAS No:
23110-15-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327. PMID: 4630977.

Ingber et al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555. PMID: 1701033.

Lowther et al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153. PMID: 9770455.

Rodriguez-Nieto et al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457. PMID: 11848509.

If you know of a relevant citation for this product please let us know.

Keywords: Fumagillin, supplier, Methionine, aminopeptidase-2, inhibitors, Proteases, Proteinases, antiangiogenics, angiogenesis, antibiotics

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