Cat. No. 1768
Chemical Name: (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-
Biological ActivityAntibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice. Analog available, TNP 470 (Cat.No. 3750).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327. PMID: 4630977.
Ingber et al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555. PMID: 1701033.
Lowther et al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153. PMID: 9770455.
Rodriguez-Nieto et al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457. PMID: 11848509.
If you know of a relevant citation for this product please let us know.
View Related Products by Product Action
Keywords: Fumagillin, supplier, Methionine, aminopeptidase-2, inhibitors, Proteases, Proteinases, antiangiogenics, angiogenesis, antibiotics, Tocris Bioscience, Aminopeptidase Inhibitors
Find multiple products by catalog number
New Products in this Area
Highly potent and selective renin inhibitorTiplaxtinin
Plasminogen activator inhibitor-1 (PAI-1) inhibitorBalicatib
Potent and selective cathepsin K inhibitorHFI 142
Insulin-regulated aminopeptidase (IRAP) inhibitorSSM 3 trifluoroacetate
Potent furin inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.