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Fumagillin

Cat. No. 1768

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Chemical Name: (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester

Biological Activity

Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice. Analog available, TNP 470 (Cat.No. 3750).

Technical Data

M.Wt:

458.55

Formula:

C₂₆H₃₄O₇

Solubility:

Soluble to 3 mM in ethanol

Storage:

Store at -20°C

CAS No:

23110-15-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Jaronski (1972) Cytochemical evidence for RNA synthesis inhibition by fumagillin. J.Antibiot. 25 327. PMID: 4630977.

Ingber et al (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 555. PMID: 1701033.

Lowther et al (1998) The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc.Natl.Acad.Sci.U.S.A. 95 12153. PMID: 9770455.

Rodriguez-Nieto et al (2001) A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res. 21 3457. PMID: 11848509.

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