R&D Systems Inc. Tocris Bioscience Boston Biochem

Nilutamide

Cat. No. 1759

Nilutamide C12H10F3N3O4 [63612-50-0]

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Alternative Name: RU 23908

Chemical Name: 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione

Biological Activity

Non-steroidal and silent antiandrogen. Binds to androgen receptors and also inhibits androgen biosynthesis in vitro. In rats in vivo it inhibits androgen-induced prostate weight increase and inhibits negative androgen-dependent gonadotropin feedback leading to an increase in luteinising hormone and testosterone. Orally active.

Technical Data

M.Wt:
317.22
Formula:
C12H10F3N3O4
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
63612-50-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Raynaud et al (1979) Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues. J.Steroid Biochem. 11 93. PMID: 385986.

Raynaud et al (1984) The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer. The Prostate 5 299. PMID: 6374639.

Raynaud et al (1985) Pharmacology and clinical studies with RU 23908 (Anandron). Prog.Clin.Biol.Res. 185A 99. PMID: 4034583.

Ayub and Levell (1987) Inhibition of rat testicular 17-α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro. J.Steroid Biochem. 28 43. PMID: 2956461.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Nilutamide, supplier, Androgen, receptor, antagonists, Orally, active, Dihydrotestosterone, Receptors, RU23908

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