R&D Systems Inc. Tocris Bioscience Boston Biochem

JP 1302 dihydrochloride

Cat. No. 2666

JP 1302 dihydrochloride C24H24N4.2HCl [1259314-65-2]

Price and Availability

For JP 1302 dihydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride

Biological Activity

α2C-adrenoceptor antagonist that displays ~ 50-fold selectivity over other α2-adrenoceptor subtypes (Ki values are 28, 1470, 1700 and 3150 nM for human α2C, α2B, α2D and α2A subtypes respectively). Potently antagonizes adrenalin-stimulated 35GTPγS binding in vitro (KB = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo.

Technical Data

M.Wt:
441.4
Formula:
C24H24N4.2HCl
Solubility:
Soluble to 100 mM in water and to 5 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
1259314-65-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Sallinen et al (2007) Pharmacological characterization and CNS effects of a novel highly selective α2C-adrenoceptor antagonist JP-1302. Br.J.Pharmacol. 150 391. PMID: 17220913.

Tricklebank (2007) JP-1302: a new tool to shed light on the roles of α2C-adrenoceptors in brain. Br.J.Pharmacol. 150 381. PMID: 17220912.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: JP 1302 dihydrochloride, supplier, Potent, selective, α2C-adrenoceptor, alpha2C-adrenoceptors, α2c-adrenergic, alpha2c-adrenergic, a2c-adrenoceptor, antagonists, Receptors, JP1302, dihydrochloride

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Guide

Highlights over 250 products for cardiovascular research. Request a copy or view PDF today.

divider line

7-TM Receptor Signaling

Written by T. Kenakin et al

7-TM Poster

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Poster

A summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request a copy or view PDF today.

divider line

Neurobiology of Parkinson's Disease

Written by A. Schapira

Parkinson's Poster

'Neurobiology and Therapeutics of Parkinson's Disease' highlights the neurobiology of Parkinson's disease and summarizes current and novel therapeutic interventions.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Poster

'Regulation of Vascular Reactivity by G-protein-coupled Receptors' summarizes the key GPCRs regulating vascular reactivity.

divider line

Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Antidepressants poster

'Antidepressants - Current and Future Targets' provides an overview of the current and future targets for the treatment of major depressive disorder.

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

New Products in this Area

TC-G 1000

Potent and selective α2D agonist

Noradrenaline bitartrate

Endogenous adrenergic hormone and neurotransmitter

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Pharmacology 2014

Pharmacology 2014

December 16 - 18, 2014

London, UK

Booth Number: 12