JP 1302 dihydrochloride

Cat. No. 2666

JP 1302 dihydrochloride C24H24N4.2HCl [1259314-65-2]

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Chemical Name: N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride

Biological Activity

α2C-adrenoceptor antagonist that displays ~ 50-fold selectivity over other α2-adrenoceptor subtypes (Ki values are 28, 1470, 1700 and 3150 nM for human α2C, α2B, α2D and α2A subtypes respectively). Potently antagonizes adrenalin-stimulated 35GTPγS binding in vitro (KB = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo.

Technical Data

M.Wt:
441.4
Formula:
C24H24N4.2HCl
Solubility:
Soluble to 100 mM in water and to 5 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
1259314-65-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Sallinen et al (2007) Pharmacological characterization and CNS effects of a novel highly selective α2C-adrenoceptor antagonist JP-1302. Br.J.Pharmacol. 150 391. PMID: 17220913.

Tricklebank (2007) JP-1302: a new tool to shed light on the roles of α2C-adrenoceptors in brain. Br.J.Pharmacol. 150 381. PMID: 17220912.

If you know of a relevant citation for this product please let us know.

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