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Bay 11-7085

Cat. No. 1743

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Alternative Name: Bay 11-7083

Chemical Name: (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile

Biological Activity

Irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC₅₀ ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.

Technical Data

M.Wt:

249.33

Formula:

C₁₃H₁₅NO₂S

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

196309-76-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Pierce et al (1997) Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272 21096. PMID: 9261113.

Hu et al (2001) An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism. Cancer Res. 61 6290. PMID: 11507084.

Scaife et al (2002) Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res. 62 6870. PMID: 12460901.

If you know of a relevant citation for this product please let us know.

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Transcription Factors

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